It appears most open source projects are headed by men; this list on Wikipedia lists 29 men in charge of open source projects. Considering the famous contributions in the history of computer science and software engineering by people like Ada Lovelace, Grace Hopper, Margaret Hamilton, and countless others, that seems a little unlikely or disappointing. Are there any well-known open source projects where a woman is in charge?
The Coccinelle project (see also on github) was started by Julia Lawall, and she's still one of the core developers. She's also considered authoritative on what it can and can't do; see eg this from LWN's coverage of the linux kernel community's response to the Meltdown and Spectre vulnerabilities:
Some developers have suggested using Coccinelle, but Julia Lawall, the creator of Coccinelle, has concluded that the task is too complex for that tool.